Retrovir

Common use
Retrovir is an anti-HIV-1 medication. It contains active substance zidovudine which is a reverse transcriptase inhibitor. This class of medications also includes zalcitabine (Hivid), didanosine (Videx), and lamivudine (Epivir), stavudine (Zerit). Retrovir increases production of T4 cells and hereby increases resistance to infection. Its ability to inhibit reverse transcriptase of HIV is 100-300 times bigger than its ability to inhibit human DNA polymerase. Retrovir is produced to treat HIV infection in adults and children over 3 months of age with symptoms of the diseases or ones with no symptoms but a significant evidence of impaired immunity.
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Dosage and direction
The recommended dose for adults is 100 mg taken every for hours. Optimal dose is 0.5-1.5 g a day. Blood cell count should be monitored on a regular basis and treatment should be interrupted if level of Hb decreases 25% and one of neutrophils does 50% from the initial level. In children under 12 years of age initial dose is counted as 180 mg per every square meter each 6 hours but not more than 200 mg every 6 hours. To prevent HIV transmission to the baby from the mother 100 mg of Retrovir is given five times daily until the time of labor starting from 14th week of pregnancy.












































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